KMID : 1377020120090050276
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Tissue Engineering and Regenerative Medicine 2012 Volume.9 No. 5 p.276 ~ p.281
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Histomorphometric study on healing of critical sized defect in rat calvaria using three different bovine grafts
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Khvan Ekaterina
Kim Ye-Mi Kim Ji-Youn Kim Myung-Rae Kim Sung-O Kim Sun-Jong
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Abstract
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The objective of this study was to evaluate the feasibility of a new xenograft material Ti-Oss¢ç(Chiyewon, Guri, Korea) by investigating the degree of new bone formation compared with that of other commonly used xenografts Bio-Oss¢ç(Geistlich Pharma AG, Wolhusen, Switzerland) and OCS-B¢ç(NIBEC, Seoul, Korea). Forty rats were used in the study. The animals were randomly allocated into four groups of 10 animals each. The Group 1¡®s calvarial defect was untreated, Group 2¡Çs defect was filled with Bio-Oss¢ç(Geistlich Pharma AG), Group 3¡Çs defect was filled with OCS-B¢ç(NIBEC), and Group 4¡Çs defect was filled with Ti-Oss¢ç(Chiyewon). The animals were sacrificed at 2 (n=5) and 8 (n=5) weeks for histomorphometric analysis. The histomorphometric analysis showed the statistically significant difference between the groups with a mean bone formation of 0.35¡¾0.10 mm (8.75%) for Bio-Oss¢ç group, 0.19¡¾0.04 mm (4.75%) for OCS-B¢ç group, 0.26¡¾0.04 mm (6.5%) for Ti-Oss¢ç group at 2 week healing period. At 8 weeks, a mean bone formation of 1.93¡¾0.18 mm (48.25%) for Bio-Oss¢ç group, 1.12¡¾0.11 mm (28%) for OCS-B¢ç group, 1.50¡¾0.28 mm (37.5%) for Ti-Oss¢ç group showed the statistically significant difference (p < 0.05). Within the limits of present study, it was concluded that the newly investigated xenograft, Ti-Oss¢ç, revealed biocompatibility and effectiveness in bone formation. Ti-Oss¢ç could be proposed as a potential material for filling osseous defects. Further clinical trials of the new bovine xenograft Ti-Oss¢ç are needed for an understanding its relevance in dentistry.
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KEYWORD
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critical-size bone defect, bone regeneration, bovine, xenograft, histomorphometry
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